[HTML][HTML] Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1
Objective SIRT1 has anti-inflammatory as well as protective effects in chondrocytes. The
object of this study was to investigate whether microRNA-449a regulates expression of …
object of this study was to investigate whether microRNA-449a regulates expression of …
MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6: possible involvement in cartilage degradation in osteoarthritis
J Yang, Y Zhou, X Liang, B Jing… - Bone & Joint Research, 2021 - boneandjoint.org.uk
Aims Osteoarthritis (OA) is characterized by persistent destruction of articular cartilage. It has
been found that microRNAs (miRNAs) are closely related to the occurrence and …
been found that microRNAs (miRNAs) are closely related to the occurrence and …
[HTML][HTML] Downregulation of microRNA-448 inhibits IL-1β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3
H Yang, D Wu, H Li, N Chen, Y Shang - Cellular & molecular biology letters, 2018 - Springer
Background Osteoarthritis is characterized by the continuous degradation of the articular
cartilage. The microRNA miR-448 has been found to be broadly involved in cellular …
cartilage. The microRNA miR-448 has been found to be broadly involved in cellular …
miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4
H Xue, Y Tu, T Ma, T Wen, T Yang, L Xue, M Cai… - Bone, 2019 - Elsevier
MicroRNAs (miRNAs, miRs) are frequently dysregulated in osteoarthritis (OA), but the role of
specific miRNAs in OA remains unclear. In this study, we found that miR-93-5p is …
specific miRNAs in OA remains unclear. In this study, we found that miR-93-5p is …
[HTML][HTML] Suppression of miR-301a alleviates LPS-induced inflammatory injury in ATDC5 chondrogenic cells by targeting Sirt1
H Chen, J Qi, Q Bi, S Zhang - International Journal of Clinical and …, 2017 - ncbi.nlm.nih.gov
Osteoarthritis is one of the most common joint diseases and is characterized by joint
inflammation. MicroRNAs (miRNA) play an important role in osteoarthritis. In this study, we …
inflammation. MicroRNAs (miRNA) play an important role in osteoarthritis. In this study, we …
[HTML][HTML] Silencing of microRNA-138-5p promotes IL-1β-induced cartilage degradation in human chondrocytes by targeting FOXC1: miR-138 promotes cartilage …
Y Yuan, GQ Zhang, W Chai, M Ni, C Xu… - Bone & joint …, 2016 - boneandjoint.org.uk
Objectives Osteoarthritis (OA) is characterised by articular cartilage degradation. MicroRNAs
(miRNAs) have been identified in the development of OA. The purpose of our study was to …
(miRNAs) have been identified in the development of OA. The purpose of our study was to …
MicroRNA‐140 is expressed in differentiated human articular chondrocytes and modulates interleukin‐1 responses
Objective MicroRNA (miRNA) are a class of noncoding small RNAs that act as negative
regulators of gene expression. MiRNA exhibit tissue‐specific expression patterns, and …
regulators of gene expression. MiRNA exhibit tissue‐specific expression patterns, and …
[HTML][HTML] MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses
F Meng, Z Zhang, W Chen, G Huang, A He… - Osteoarthritis and …, 2016 - Elsevier
Summary Objective Metalloproteinases (MMPs) are key regulators of osteoarthritis (OA) and
collagen degradation and have been shown to participate in endochondral ossification. The …
collagen degradation and have been shown to participate in endochondral ossification. The …
miR-122/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis
Y Bai, K Chen, J Zhan, M Wu - Bioscience Reports, 2020 - portlandpress.com
Abstract Background/Aims: MicroRNAs (miRNAs) are involved in the pathogenesis of
osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 …
osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 …
MicroRNA‐127‐5p regulates matrix metalloproteinase 13 expression and interleukin‐1β–induced catabolic effects in human chondrocytes
SJ Park, EJ Cheon, MH Lee, HA Kim - Arthritis & Rheumatism, 2013 - Wiley Online Library
Objective MicroRNAs (miRNAs), small noncoding RNA molecules, are involved in the
pathogenesis of various diseases such as cancer and arthritis. The aim of this study was to …
pathogenesis of various diseases such as cancer and arthritis. The aim of this study was to …