The myocardium contains myocyte and non-myocyte cells. A disproportionate growth of the
nonmyocyte cell population can alter myocardial structure and lead to pathologic …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Obesity is a growing epidemiological problem, as two-thirds of the adult population are
carrying excess weight. It is a risk factor for the development of cardiovascular diseases …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

This study had two objectives:(a) to determine the accumulation of collagen and its structural
remodelling in the hypertrophied rat left ventricle after 4 and 8 weeks of abdominal aorta …

An exaggerated interstitial and perivascular deposition of fibrillar collagen has been
demonstrated in myocardial hypertrophy due to hypertension. 3 Mechanical stress forces …

In hypertensive heart disease, reactive myocardial fibrosis represents as an excessive
accumulation of fibrillar collagen within the normal connective tissue structures of the …

Myocardial fibrillar collagen is considered an important determinant of increased ventricular
stiffness in pressure-overload (PO)-induced cardiac hypertrophy. Chronic PO was created in …

The pathogenesis of fibrosis and the functional features of pressure overload myocardial
hypertrophy are still controversial. The objectives of the present study were to evaluate the …