Nanoscale Biomaterials Engineering for Hemostatic Applications
K Jolly - 2022 - rave.ohiolink.edu
Severe hemorrhage associated with trauma, surgery, and other coagulopathies can be life-
threatening and requires rapid hemostatic management. The clinical gold standard for this is …
threatening and requires rapid hemostatic management. The clinical gold standard for this is …
[PDF][PDF] Targeted Modulation of Fibrin Formation and Stability with Intravenous Hemostatic Nanotechnologies
K Jolly, A Girish, A Rechhione, M de la Fuente… - abstracts.biomaterials.org
Statement of Purpose: Severe hemorrhage associated with trauma, surgery, and other
coagulopathies can be lifethreatening and requires rapid hemostatic management1. For …
coagulopathies can be lifethreatening and requires rapid hemostatic management1. For …
Platelet-inspired intravenous nanomedicine for injury-targeted direct delivery of thrombin to augment hemostasis in coagulopathies
A Girish, K Jolly, N Alsaadi, M de la Fuente… - ACS …, 2022 - ACS Publications
Severe hemorrhage associated with trauma, surgery, and congenital or drug-induced
coagulopathies can be life-threatening and requires rapid hemostatic management via …
coagulopathies can be life-threatening and requires rapid hemostatic management via …
Synthetic strategies for engineering intravenous hemostats
While there are currently many well-established topical hemostatic agents for field
administration, there are still limited tools to staunch bleeding at less accessible injury sites …
administration, there are still limited tools to staunch bleeding at less accessible injury sites …
Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage
AJ Srinivasan, ZA Secunda… - Journal of Trauma …, 2023 - journals.lww.com
Background Early platelet transfusion is associated with reduced mortality in traumatic
hemorrhage. However, platelet usage is severely limited due to challenges of donor …
hemorrhage. However, platelet usage is severely limited due to challenges of donor …
Supramolecularly functionalized platelets for rapid control of hemorrhage
Excessive bleeding has always been of great medical challenge, particularly in trauma and
surgery. Due to the fast clearance of medicine and complex hemodynamics during …
surgery. Due to the fast clearance of medicine and complex hemodynamics during …
Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability
Hemorrhage is a prime cause of death in civilian and military traumatic injuries, whereby a
significant proportion of death and complications occur prior to paramedic arrival and …
significant proportion of death and complications occur prior to paramedic arrival and …
Biomaterials and advanced technologies for hemostatic management of bleeding
DSA Hickman, CL Pawlowski, UDS Sekhon… - Advanced …, 2018 - Wiley Online Library
Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …
associated, or drug‐induced blood disorders can cause significant morbidities and …
Nanofibrous hemostatic materials: Structural design, fabrication methods, and hemostatic mechanisms
X Lu, X Li, J Yu, B Ding - Acta Biomaterialia, 2022 - Elsevier
Abstract Development of rapid and effective hemostatic materials has always been the focus
of research in the healthcare field. Nanofibrous materials which recapitulate the delicate …
of research in the healthcare field. Nanofibrous materials which recapitulate the delicate …
Synthetic platelets for treatment of traumatic hemorrhage and thrombocytopenia
AS Gupta - Blood, 2019 - Elsevier
Platelets are primarily responsible for staunching bleeding by forming a 'platelet plug'and
further amplifying thrombin generation on its surface to facilitate fibrin formation, leading to …
further amplifying thrombin generation on its surface to facilitate fibrin formation, leading to …