Nanoscale Biomaterials Engineering for Hemostatic Applications

K Jolly - 2022 - rave.ohiolink.edu
Severe hemorrhage associated with trauma, surgery, and other coagulopathies can be life-
threatening and requires rapid hemostatic management. The clinical gold standard for this is …

[PDF][PDF] Targeted Modulation of Fibrin Formation and Stability with Intravenous Hemostatic Nanotechnologies

K Jolly, A Girish, A Rechhione, M de la Fuente… - abstracts.biomaterials.org
Statement of Purpose: Severe hemorrhage associated with trauma, surgery, and other
coagulopathies can be lifethreatening and requires rapid hemostatic management1. For …

Platelet-inspired intravenous nanomedicine for injury-targeted direct delivery of thrombin to augment hemostasis in coagulopathies

A Girish, K Jolly, N Alsaadi, M de la Fuente… - ACS …, 2022 - ACS Publications
Severe hemorrhage associated with trauma, surgery, and congenital or drug-induced
coagulopathies can be life-threatening and requires rapid hemostatic management via …

Synthetic strategies for engineering intravenous hemostats

LW Chan, NJ White, SH Pun - Bioconjugate chemistry, 2015 - ACS Publications
While there are currently many well-established topical hemostatic agents for field
administration, there are still limited tools to staunch bleeding at less accessible injury sites …

Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage

AJ Srinivasan, ZA Secunda… - Journal of Trauma …, 2023 - journals.lww.com
Background Early platelet transfusion is associated with reduced mortality in traumatic
hemorrhage. However, platelet usage is severely limited due to challenges of donor …

Supramolecularly functionalized platelets for rapid control of hemorrhage

YF Ding, Q Huang, X Quan, Q Cheng, S Li, Y Zhao… - Acta Biomaterialia, 2022 - Elsevier
Excessive bleeding has always been of great medical challenge, particularly in trauma and
surgery. Due to the fast clearance of medicine and complex hemodynamics during …

Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability

RA Eissa, HA Saafan, AE Ali, KM Ibrahim, NG Eissa… - Nanoscale, 2022 - pubs.rsc.org
Hemorrhage is a prime cause of death in civilian and military traumatic injuries, whereby a
significant proportion of death and complications occur prior to paramedic arrival and …

Biomaterials and advanced technologies for hemostatic management of bleeding

DSA Hickman, CL Pawlowski, UDS Sekhon… - Advanced …, 2018 - Wiley Online Library
Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …

Nanofibrous hemostatic materials: Structural design, fabrication methods, and hemostatic mechanisms

X Lu, X Li, J Yu, B Ding - Acta Biomaterialia, 2022 - Elsevier
Abstract Development of rapid and effective hemostatic materials has always been the focus
of research in the healthcare field. Nanofibrous materials which recapitulate the delicate …

Synthetic platelets for treatment of traumatic hemorrhage and thrombocytopenia

AS Gupta - Blood, 2019 - Elsevier
Platelets are primarily responsible for staunching bleeding by forming a 'platelet plug'and
further amplifying thrombin generation on its surface to facilitate fibrin formation, leading to …