Hutchinson–Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal
premature aging syndrome. HGPS is most often derived from a de novo point mutation in the …

Hutchinson-Gilford progeria syndrome (HGPS, progeria) is an extremely rare premature
aging disorder affecting children, with a disease incidence of∼ 1 in 18 million individuals …

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging condition that involves
genetic mutations, resulting in debilitating phenotypic features. The present state of …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which ultimately …

The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by
mutations of the LMNA gene leading to increased production of a partially processed form of …

Lamin A/C encoded by the LMNA gene is an essential component for maintaining the
nuclear structure. Mutation in the lamin A/C leads to a group of inherited disorders is known …

Hutchinson-Gilford progeria syndrome (HGPS) is one of the most severe disorders among
laminopathies—a heterogeneous group of genetic diseases with a molecular background …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to
a severe premature ageing phenotype, caused by mutations in the LMNA gene. The LMNA …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal genetic disorder that is
characterized by segmental accelerated aging. The major causal mutation associated with …