Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea
Z Yang, Z Cao, W Wang, Y Chen, W Huang, S Jiao… - Bioorganic …, 2023 - Elsevier
Abstract Human carboxylesterase 2 (hCES2A), one of the most important serine hydrolases
distributed in the small intestine and colon, plays a crucial role in the hydrolysis of various …
distributed in the small intestine and colon, plays a crucial role in the hydrolysis of various …
In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors
Carboxylesterase 1 (CES1) is the major hydrolase in human liver. The enzyme is involved in
the metabolism of several important therapeutic agents, drugs of abuse, and endogenous …
the metabolism of several important therapeutic agents, drugs of abuse, and endogenous …
Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2
J Wang, ET Williams, J Bourgea, YN Wong… - Drug Metabolism and …, 2011 - ASPET
Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …
Carboxylesterases
B Yan - Encyclopedia of drug metabolism and interactions, 2011 - Wiley Online Library
Abstract Carboxylesterases (CESs, EC 3.1. 1.1) constitute a large class of enzymes that
hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide …
hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide …
Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino) …
SP Sanghani, SK Quinney, TB Fredenburg… - Drug Metabolism and …, 2004 - ASPET
Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more
soluble acid, alcohol, and amine products. They belong to a multigene family with about …
soluble acid, alcohol, and amine products. They belong to a multigene family with about …
Regulations of xenobiotics and endobiotics on carboxylesterases: a comprehensive review
Y Xu, C Zhang, W He, D Liu - European journal of drug metabolism and …, 2016 - Springer
Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …
ester-and amide-containing compounds. CESs dominate both the biotransformation of …
Human carboxylesterase 1: from drug metabolism to drug discovery
MR Redinbo, S Bencharit, PM Potter - 2003 - portlandpress.com
Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism
and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of …
and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of …
Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2
YS Zhao, XK Qian, XQ Guan, PF Song, YQ Song… - Bioorganic …, 2020 - Elsevier
Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
K Ohura, Y Igawa, M Tanaka, K Matsumoto… - Drug Metabolism and …, 2020 - ASPET
In contrast to a single human carboxylesterase 2 (CES2) isozyme (hCE2), three CES2
genes have been identified in cynomolgus monkeys: mfCES2A, mfCES2B, and mfCES2C …
genes have been identified in cynomolgus monkeys: mfCES2A, mfCES2B, and mfCES2C …
Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2
LW Zou, YG Li, P Wang, K Zhou, J Hou, Q Jin… - European journal of …, 2016 - Elsevier
Abstract Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the
human intestine and various tumour tissues, plays important roles in the oral bioavailability …
human intestine and various tumour tissues, plays important roles in the oral bioavailability …