Benzil has been identified as a potent selective inhibitor of carboxylesterases (CEs).
Essential components of the molecule required for inhibitory activity include the dione …

The aims of this study were to develop a robust method for simultaneous quantification of
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …

Human carboxylesterase 1 (hCE1) exhibits broad substrate specificity and is involved in
xenobiotic processing and endobiotic metabolism. We present and analyze crystal …

Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with
respect to their hydrolytic function on (pro) drugs, whereas their physiological role in lipid …

Carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and
exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid …

Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …

In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …

Esterases participate in the metabolism of~ 10% of the clinical drugs that contain ester or
amide bonds, but the esterases mediated drug/herb-drug interactions (DDIs or HDIs) have …

Carboxylesterases (CES, EC 3.1. 1.1) hydrolyze ester, amide, and carbamate bonds found
in xenobiotics and endobiotics. Multiple CES genes exist in mammals with evidence of …

Pyrethroids are broad-spectrum insecticides that widely used in many countries, while
humans may be exposed to these toxins by drinking or eating pesticide-contaminated foods …