Abstract Human carboxylesterase 2A (hCES2A) is a key serine hydrolase responsible for
the metabolic clearance of large number of compounds bearing the ester-or amide-bond (s) …

Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing
xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT-11) …

Carboxylesterases (CEs) are ubiquitous enzymes that are responsible for the metabolism of
xenobiotics, including drugs such as irinotecan and oseltamivir. Inhibition of CEs …

Prodrug is a useful approach for improving the bioavailability of therapeutic agents through
increased passive transport. Carboxylesterases (CESs, EC. 3.1. 1.1.) that show ubiquitous …

Carboxylesterases (CEs) are ubiquitously expressed proteins that are responsible for the
detoxification of xenobiotics. They tend to be expressed in tissues likely to be exposed to …

The dose-limiting toxicity of the highly effective anticancer agent 7-ethyl-10-[4-(1-piperidino)-
1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is delayed diarrhea. This is …

Carboxylesterases (CEs) are important enzymes that catalyze biological detoxification,
hydrolysis of certain pesticides, and metabolism of many esterified drugs. The development …

Abstract Carboxylesterase 2 (CES2), the main carboxylesterase expressed in human
intestine, is an increasingly important enzyme in anti-cancer combined therapies for the …

Human carboxylesterase 2 (hCE2) is one of the most abundant esterases distributed in
human small intestine and colon, which participates in the hydrolysis of a variety of ester …

Studying factors that cause interindividual variability of carboxylesterase 1 (CES1) activity is
currently difficult due to limited methods. Here, fluorogenic tools for measuring CES1 activity …