Breast and ovarian cancers are some of the most common tumors in females, and the
genetic predisposition is emerging as one of the key risk factors in the development of these …

The current study aimed to identify new breast and/or ovarian cancer predisposition genes.
For that, whole‐exome sequencing (WES) was performed in the germline DNA of 52 non …

Several genes associated with hereditary ovarian cancer have been discovered as a result
of the work done with next generation sequencing. It is estimated that approximately 23% of …

Objective Genetic predisposition to ovarian cancer is well documented. With the advent of
next generation sequencing, hereditary panel testing provides an efficient method for …

ATM, BRCA1, BRCA2, CHEK2, PALB2 and TP53 are all established breast cancer
susceptibility genes. Over the past 30 years, many other genes have been proposed as …

Women with hereditary breast and ovarian cancer (HBOC) syndrome represent a unique
group who are diagnosed at a younger age and result in an increased lifetime risk for …

Breast and ovarian cancer (BC/OC) predisposition has been attributed to a number of high‐
and moderate to low‐penetrance susceptibility genes. With the advent of next generation …

Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in
women in developed countries, after breast, lung, and colorectal cancer. In the United States …

NGS‐based multiple gene panel resequencing in combination with a high resolution CGH‐
array was used to identify genetic risk factors for hereditary breast and/or ovarian cancer in …

Background Germ line mutations in BRCA1 and BRCA2 (BRCA1/2) and other susceptibility
genes have been identified as genetic causes of hereditary breast and ovarian cancer …