Even though B-lymphocyte development is one of the best understood models for cell
differentiation in the hematopoetic system, recent advances in cell sorting and functional …

To better understand the process of B-lymphocyte lineage restriction, we have investigated
molecular and functional properties in early B-lineage cells from Pax-5–deficient animals …

Considerable progress has been made over the past few years in determining the key
molecular players that regulate the commitment and development of early B-lineage cells in …

Commitment of hematopoietic progenitor cells to B-lymphoid cell fate has been suggested to
coincide with the development of PAX5-expressing B220+ CD19+ pro–B cells. We have …

The expression of lineage-associated genes, as well as the survival and expansion of
committed B cell progenitors, is controlled by multiple transcriptional regulators and growth …

The maturation of B‐lymphoid cells from hematopoietic stem cells in the bone marrow is a
complex process under control of interplay between extrinsic and intrinsic factors. In addition …

B cells have to progress through various checkpoints during their process of development.
The three transcription factors E2A, EBF (early B cell factor) and Pax5 play essential roles in …

Pax5 is an essential regulator of B cell identity and function. Here, we used transgenesis
and deletion mapping to identify a potent enhancer in intron 5 of the Pax5 locus. This …

Alternative lineage restriction and B cell fate commitment require the transcription factor
Pax5, but the function of early B cell factor (EBF) in these processes remains mostly …

To investigate molecular events involved in the regulation of lymphoid lineage commitment,
we crossed λ5 reporter transgenic mice to Rag1-GFP knockin mice. This allowed us to …