Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia

RO Akinyemi, EB Mukaetova-Ladinska… - Current Alzheimer …, 2013 - ingentaconnect.com
Age is the strongest risk factor for brain degeneration whether it results from vascular or
neurodegenerative mechanisms or both. To evaluate the current views on the impact of …

Role of vascular risk factors and vascular dysfunction in Alzheimer's disease

DL Dickstein, J Walsh, H Brautigam… - Mount Sinai Journal …, 2010 - Wiley Online Library
Recent findings indicate that vascular risk factors and neurovascular dysfunction play
integral roles in the pathogenesis of Alzheimer's disease. In addition to aging, the most …

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

C Iadecola - Acta neuropathologica, 2010 - Springer
There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

Vascular disease and dementias: paradigm shifts to drive research in new directions

MA Kling, JQ Trojanowski, DA Wolk, VMY Lee… - Alzheimer's & …, 2013 - Elsevier
Vascular disease was once considered the principal cause of aging-related dementia. More
recently, however, research emphasis has shifted to studies of progressive …

Vascular risk factors and Alzheimer's disease

JT O'Brien, HS Markus - BMC medicine, 2014 - Springer
Vascular factors are now established risk factors for cognitive decline, both for dementia and
its two main subtypes: Alzheimer's disease (AD) and vascular dementia. Their impact likely …

Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease☆

J Shi, G Perry, MA Smith, RP Friedland - Neurobiology of Aging, 2000 - Elsevier
Alzheimer's disease (AD) and cerebrovascular dementia (CVD) are two major causes of
senile dementia in elderly individuals. Mounting evidence from epidemiological, clinical, and …

Vascular factors in dementia: an overview

C DeCarli - Journal of the neurological sciences, 2004 - Elsevier
Alzheimer's disease and cerebrovascular disease are two illnesses common to the elderly.
Conventional wisdom has sought to separately describe and treat these two diseases …

Does vascular pathology contribute to Alzheimer changes?

RN Kalaria, R Akinyemi, M Ihara - Journal of the neurological sciences, 2012 - Elsevier
In recent years there has been increased interest in whether vascular disease contributes to
Alzheimer's disease (AD). This review considers how modifiable risk factors such as …

Treating vascular risk factors and maintaining vascular health: is this the way towards successful cognitive ageing and preventing cognitive decline?

K Alagiakrishnan, P McCracken… - Postgraduate medical …, 2006 - academic.oup.com
Dementia is a progressive disorder that typically worsens with time and from which recovery
is unlikely. The incidence of dementia increases exponentially with ageing and is an …

Neurovascular alterations in vascular dementia: emphasis on risk factors

S Lecordier, D Manrique-Castano… - Frontiers in aging …, 2021 - frontiersin.org
Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …