Heparin-induced thrombocytopenia

GM Arepally - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy
caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic …

Heparin-induced thrombocytopenia

GM Arepally, TL Ortel - Annual review of medicine, 2010 - annualreviews.org
Heparin-induced thrombocytopenia (HIT) is an immune-mediated hypercoagulable disorder
caused by antibodies to platelet factor 4 (PF4) and heparin. HIT develops in temporal …

Heparin-induced thrombocytopenia

GM Lee, GM Arepally - Hematology 2013, the American Society …, 2013 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies
that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered …

Heparin-induced thrombocytopenia: a focus on thrombosis

GM Arepally, A Padmanabhan - Arteriosclerosis, thrombosis, and …, 2021 - Am Heart Assoc
Heparin-induced thrombocytopenia is an immune-mediated disorder caused by antibodies
that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and …

Heparin‐induced thrombocytopenia

A Greinacher - Journal of thrombosis and haemostasis, 2009 - Wiley Online Library
Heparin‐induced thrombocytopenia (HIT), typically occurring in the second week of heparin
therapy, is an antibody‐mediated adverse drug reaction associated with increased …

Studies of the immune response in heparin-induced thrombocytopenia

TE Warkentin, JAI Sheppard, JC Moore… - Blood, The Journal …, 2009 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating antibodies that
recognize PF4/heparin complexes. Uncertainties remain regarding HIT immunobiology …

Pathogenesis of heparin-induced thrombocytopenia

GM Arepally, DB Cines - Translational Research, 2020 - Elsevier
There are currently no effective substitutes for high intensity therapy with unfractionated
heparin (UFH) for cardiovascular procedures based on its rapid onset of action, ease of …

[HTML][HTML] Autoimmune heparin‐induced thrombocytopenia

A Greinacher, K Selleng, TE Warkentin - Journal of Thrombosis and …, 2017 - Elsevier
Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of
anti‐platelet factor 4 (PF4)–polyanion antibodies that are able to activate platelets strongly …

Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications

L Rauova, L Zhai, MA Kowalska, GM Arepally… - Blood, 2006 - ashpublications.org
Heparin-induced thrombocytopenia (HIT) antibodies recognize complexes between heparin
and platelet factor 4 (PF4). Heparin and PF4 bind HIT antibodies only over a narrow molar …

Clinical picture of heparin-induced thrombocytopenia

TE Warkentin - Heparin-induced thrombocytopenia, 2012 - taylorfrancis.com
INTRODUCTION Heparin-induced thrombocytopenia (HIT) is a distinct clinicopathologic
syndrome caused by platelet-activating antibodies that recognize complexes of platelet …