Aberrant DNA base excision repair (BER) contributes to malignant transformation. However,
inter-individual variations in DNA repair capacity plays a key role in modifying breast cancer …

In previous studies, we found that adenomatous polyposis coli (APC) blocks the base
excision repair (BER) pathway by interacting with 5′-flap endonuclease 1 (Fen1). In this …

Base excision repair (BER) addresses the numerous base lesions and strand breaks
induced by exogenous and endogenous stressors daily. The complexity and importance of …

Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular
functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal …

Our previous studies have shown that treatment with cigarette smoke condensate (CSC)
transforms normal breast epithelial cell line, MCF-10A. In the present study, the mechanism …

Background Impaired DNA repair mechanism is one of the cancer hallmarks. Flap
Endonuclease 1 (FEN1) is essential for genomic integrity. FEN1 has key roles during base …

Aim As a tumor suppressor, FEN1 plays an essential role in preventing tumorigenesis. Two
functional germline variants (-69G> A and 4150G> T) in the FEN1 gene have been …

Colorectal cancer (CRC) is the third leading cause of death in both men and women in North
America. Despite chemotherapeutic efforts, CRC is associated with a high degree of …

Prevailing literature suggests diversified cellular functions for the adenomatous polyposis
coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair …

Recently, we found an interaction between adenomatous polyposis coli (APC) and DNA
polymerase β (pol-β) and showed that APC blocks strand-displacement synthesis of long …