The hypothalamus uses hormones and the autonomic nervous system to balance energy
fluxes in the body. Here we show that the autonomic nervous system has a distinct …

Maintenance of glucose homeostasis is mandatory for organismal survival. It is
accomplished by complex and coordinated interplay between glucose detection …

Regulation of energy metabolism is controlled by the brain, in which key central neuronal
circuits process a variety of information reflecting nutritional state. Special sensory and …

Obesity is a rapidly increasing public health concern worldwide as a major risk factor for
numerous disorders, including diabetes, hypertension and heart disease. Despite …

The prevalence of metabolic disorders, including type 2 diabetes mellitus, continues to
increase worldwide. Although newer and more advanced therapies are available, current …

The central nervous system (CNS) has an important role in the regulation of peripheral
insulin sensitivity and glucose homeostasis. Research in this dynamically developing field …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

The brain influences glucose homeostasis, partly by supplemental control over insulin and
glucagon secretion. Without this central regulation, diabetes and its complications can …

The in vivo radioautographic method has been applied to elucidate the mechanism of direct
peptide hormone “feedback” action in the CNS. Using this method we have identified the …

A large body of data gathered over the last decades has delineated the neuronal pathways
that link the central nervous system with the autonomic innervation of the endocrine …