Background Dialysis patients suffer from a high burden of cardiovascular disease (CVD).
Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous …

Background: Experimental studies indicate that Klotho deficiency is a pathogenic factor for
CKD-related complications, including cardiovascular disease (CVD). However, the …

Introduction: This study aimed to investigate the relationship between circulating soluble
Klotho concentration and all-cause mortality in individuals with chronic kidney disease …

Background: The correlation between soluble Klotho (sKlotho) level and vascular
calcification (VC) in patients with chronic kidney disease (CKD) remains controversial. Using …

Objective. The prognostic role of Klotho in patients with chronic kidney disease is still
controversial. Therefore, we performed this meta‐analysis to assess the relationship …

Background and aims Evidence indicates that serum Klotho concentration is associated with
mortality in patients with chronic kidney disease (CKD). However, evidence on this …

To explore the optimal cut-off values of Klotho for predicting all-cause and cardiovascular
mortality among chronic kidney disease (CKD) patients. Klotho was measured in 40–79 …

Background Klotho gene was identified as an aging suppressor. In animals, klotho
overexpression extends life span, and defective klotho results in rapid aging and early …

Background Chronic kidney disease (CKD) is diagnosed in more than 26 million US people,
which increases the risk of many adverse events. α-Klotho was reported to have potential …

Klotho is a single-pass transmembrane protein that exerts its biological functions through
multiple modes. Membrane-bound Klotho acts as coreceptor for the major phosphatonin …