Background Acute kidney injury (AKI) is a common complication after cardiac surgery and
percutaneous coronary interventions which markedly worsens prognosis. In recent years …

Purpose End-stage renal disease patients on chronic hemodialysis (HD) have a shortened
life expectancy compared to the general population. The aim of this study was to evaluate a …

Background Limited data exist on the association between serum Klotho concentration and
heart failure (HF). Methods and results We conducted a cross-sectional study of 13,625 …

Background: Chronic kidney disease (CKD) reduces both Klotho expression and its
shedding into circulation, an effect that accelerates progression and cardiovascular …

Objective: to determine the role of serum Klotho (s-Klotho) protein levels changes in patients
with different stages of chronic kidney disease (CKD). Methods: The study involved 130 …

Background Klotho is a single-pass transmembrane protein, which appears to be implicated
in aging. The purpose of the present study was to characterize the relationship between the …

Despite medical progress, high morbidity and mortality rates have persisted in patients with
end-stage renal disease (ESRD). The role in atherosclerosis and cardiovascular disease of …

Abstract Background Soluble Klotho has multiple systemic salutary effects. In animals, both
acute and chronic kidney disease models display systemic Klotho deficiency. As such, there …

The Klotho protein, known as an antiaging protein, is expressed mainly in the kidney, and
kidney disorders may contribute to the disrupted expression of renal Klotho. The purpose of …

Background Hemodialysis patients suffer from a serious threat of cerebrovascular disease.
Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and …