[HTML][HTML] Rapid decline of kidney function in diabetic kidney disease is associated with high soluble Klotho levels

F Bob, A Schiller, R Timar, D Lighezan… - Nefrología (English …, 2019 - Elsevier
Background Klotho is found in two forms: a transmembrane form and a soluble form (s-
Klotho). In order to be excreted, s-Klotho, that is too large to be filtered, will probably reach …

Association between anemia and serum Klotho in middle-aged and older adults

C An, X Chen, D Zheng - BMC nephrology, 2023 - Springer
Abstract Background The role of Klotho as a multifunctional protein in anemia is unclear.
This study aimed to determine the association between anemia and serum Klotho …

Association of serum soluble α‑klotho with risk of kidney stone disease: a population-based cross-sectional study

X Hu, X Li, N Ye, Z Zhou, G Li, F Jiang - World Journal of Urology, 2024 - Springer
Background The aim of the study was to explore the association of serum soluble klotho with
kidney stone disease (KSD) in the general population over the age of 40 years in the United …

[引用][C] Nephrocardioprotective role of the Klotho protein circulating form in patients with chronic kidney disease

LY Milovanova, YS Milovanov, LV Kozlovskaya - Clinical nephrology, 2013 - rjsvd.com
Keywords acute kidney injury albuminuria anemia arterial hypertension children chronic
glomerulonephritis chronic heart failure chronic kidney disease chronic renal failure covid …

Klotho and chronic kidney disease

MC Hu, M Kuro-o, OW Moe - Phosphate and Vitamin D in Chronic …, 2013 - karger.com
Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

Lower soluble Klotho levels in the pretransplant period are associated with an increased risk of renal function decline in renal transplant patients

Y Shikida, M Mizobuchi, O Yoshitake… - Therapeutic …, 2021 - Wiley Online Library
Serum soluble Klotho levels are associated with renal function in predialysis patients with
chronic kidney disease. However, few reports exist regarding the association between …

Association between serum klotho and kidney stones in us middle-aged and older individuals with diabetes mellitus: results from 2007 to 2016 National Health and …

Y Xiao, Z Xiao - American Journal of Nephrology, 2023 - karger.com
Introduction: Kidney stones (KSs) are associated with hematuria and renal failure and pose
a significant clinical and public health concern. Diabetes is associated with a higher risk of …

Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism

J Liu, H Wang, Q Liu, S Long, Y Wu, N Wang, W Lin… - Cell & Bioscience, 2024 - Springer
Background The anti-aging protein Klotho plays a protective role in kidney disease, but its
potential as a biomarker for chronic kidney disease (CKD) is controversial. Additionally, the …

[HTML][HTML] A Klotho-Based Machine Learning Model for Prediction of both Kidney and Cardiovascular Outcomes in Chronic Kidney Disease

Y Wang, Y Shi, T Xiao, X Bi, Q Huo, S Wang, J Xiong… - Kidney …, 2024 - karger.com
Introduction: This study aimed to develop and validate machine learning (ML) models based
on serum Klotho for predicting end-stage kidney disease (ESKD) and cardiovascular …

[HTML][HTML] Associations of serum soluble klotho and fibroblast growth factor 23 with carotid artery calcification in patients undergoing continuous ambulatory peritoneal …

N Guo, X Chen, Y Cao, G Lu - Medicine, 2021 - journals.lww.com
This study aimed to assess the associations of serum soluble klotho and fibroblast growth
factor 23 (FGF-23) with the occurrence of carotid artery calcification. Peritoneal dialysis …