Background The prevalence of hypertension in young women is lower than that in age-
matched men while the prevalence of hypertension in women is significantly increased after …

Abstract Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play
endothelial protective roles. However, it remains unclear whether estrogen could regulate …

Background We have previously shown that essential hypertension in humans and
spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and …

Background Hypertension is, amongst others, characterized by endothelial dysfunction and
vascular remodeling. As sphingolipids have been implicated in both the regulation of …

Sphingolipids (SLs) have a biomodulatory role in physiological as well as pathological
cardiovascular conditions. This study aims to assess the variation of SL mediators and …

Sphingomyelinases ensure ceramide production and play an integral role in cell turnover,
inward budding of vesicles and outward release of exosomes. Recent data indicate a …

Background: Menopause is associated with increased arterial stiffness, an independent
marker of cardiovascular risk. Omega-3 polyunsaturated fatty acids (N3-PUFAs) are thought …

Atherosclerosis is caused by many factors, one of which is oxidative stress. We recently
demonstrated that systemic oxidative stress increased secretory sphingomyelinase …

Bioactive sphingolipids are emerging as key regulators of vascular function and
homeostasis. While most of the clinical studies have been devoted to profile circulating …

Objective: Long-chain n-3 polyunsaturated fatty acids from oily fish reduce blood pressure
(BP) in hypertension. Previously, we demonstrated that hypertension is associated with …