Inadequate pain and/or stress management in preterm‐and term‐born infants has been
associated with increased morbidity and even mortality. However, exposure to …

Recent advances in neonatal intensive care include and are partly attributable to growing
attention for comfort and pain control in the term and preterm infant requiring intensive care …

The past 4 decades have witnessed enormous leaps in understanding of the acute and long-
term impacts of neonatal pain and stress. Healthy infants experience roughly 12 skin …

Approximately 30 years ago, the myth that nervous system immaturity precluded neonates
from pain perception and its negative effects was rejected. Neurobiologists further explored …

Inadequate pain management but also inappropriate use of analgesics in early infancy has
negative effects on neurodevelopmental outcome. As a consequence, neonatal pain …

Rapid advances have been made in the use of pharmacological analgesia and sedation for
newborns requiring neonatal intensive care. Practical considerations for the use of systemic …

Inadequate management of pain in early human life contributes to impaired
neurodevelopmental outcome and alters pain thresholds, pain or stress-related behavior …

Despite the widespread use of potent sedative and analgesic agents in adult patients, it is
remarkable that systemic analgesia and sedation have not been administered routinely to …

Optimal analgesia remains a major challenge for all involved in the care of (critically) ill
newborns. The rapid changes in liver metabolism involving maturation of liver enzymes and …

Background Providing optimal pain relief is a challenging task when caring for premature
infants. The aim of this study was to compare the long-term cognitive, motor, and behavioral …