Lipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers
of organelle identity. Because of these important roles, the kinases and phosphatases that …

As obligate parasites of cellular processes, viruses must take over cellular macromolecular
machinery. It is also becoming clear that viruses routinely control intracellular signaling …

PI3K-Akt pathway is an important mechanism through which viral infection influences
various cell functions. Activating PI3K-Akt signaling is a strategy employed by viruses to slow …

Several RNA viruses have recently been shown to hijack members of the host
phosphatidylinositol (PtdIns) 4-kinase (PI4K) family of enzymes. They use PI4K to generate …

Abstract The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-
phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the …

As viruses do not possess genes encoding for proteins required for translation, energy
metabolism or membrane biosynthesis, they are classified as obligatory intracellular …

Phosphoinositides (PI) are phospholipids that mediate signaling cascades in the cell by
binding to effector proteins. Reversible phosphorylation of the inositol ring at positions 3, 4 …

Many important cellular functions are regulated by the selective recruitment of proteins to
intracellular membranes mediated by specific interactions with lipid phosphoinositides. The …

Over the course of evolution, viruses have developed the ability to modulate a variety of host
cell signalling pathways. Inhibition of apoptosis, in particular, has become recognized as an …

Phosphatidylinositol 4-kinase III beta (PI4KIIIβ) is an essential enzyme in mediating
membrane transport, and plays key roles in facilitating viral infection. Many pathogenic …