Meal ingestion increases body temperature in multiple species, an effect that is blunted by
obesity. However, the mechanisms responsible for these phenomena remain incompletely …

High-fat (HF) feeding induces a transient increase in caloric intake and enhances energy
expenditure. We hypothesized that leptin is necessary for homeostatic restoration of the HF …

In addition to playing a central role in energy homeostasis, leptin is also an important player
in the inflammatory response. Systemic inflammation is accompanied by fever (less severe …

Of the central nervous system receptors that could mediate the energy balance effects of
leptin, those of the hypothalamic arcuate nucleus receive the greatest attention …

To elucidate the role of leptin in regulating neuroendocrine and metabolic function during an
acute fast, six to eight healthy, lean men were studied under four separate conditions: a …

The mutation of the ob gene is known to induce a phenotype of obesity accompanied by
symptoms including enhanced production of glucocorticoid. Chronic administration to ob/ob …

Leptin regulates body weight in mice by decreasing appetite and increasing sympathetic
nerve activity (SNA), which increases energy expenditure in interscapular brown adipose …

Leptin is a principal adipose-derived hormone mostly implicated in the regulation of energy
balance through the activation of anorexigenic neuronal pathways. Comprehensive studies …

BACKGROUND:: Overconsumption of calorically dense foods contributes substantially to the
current obesity epidemic. The adiposity hormone leptin has been identified as a potential …

The discovery of leptin has enhanced understanding of the interrelationship between
adipose energy stores and neuronal circuits in the brain involved in energy balance and …