Background: Magnolol has shown the potential anticancer properties against a variety of
cancers. However, the role of magnolol in cholangiocarcinoma (CCA) cells is unknown. In …

Deoxycholic acid (DCA) has been implicated in colorectal carcinogenesis in humans with
effects on proliferation and apoptosis, mediated at least in part by activation of transcription …

Background/Aims: Caffeic acid (CA) is known to possess multiple biological activities
including anti-cancer activities. However, the molecular mechanisms underlying these …

Purpose: Cytotoxic chemotherapy has been used to treat patients with metastatic colorectal
cancer with limited success. Therefore novel chemotherapeutic approaches are needed …

SUMMARY 1 Bax is a very important pro‐apoptosis molecule. HCT116/Bax−/–cells do not
express the pro‐apoptosis Bcl‐2 family member, Bax. In the present study, the anticancer …

Chemotherapy aims to limit proliferation and induce apoptotic cell death in tumor cells.
Owing to blockade of signaling pathways involved in cell survival and proliferation, nuclear …

Background Lung cancer is the leading cause of cancer-associated death worldwide and is
classified into non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) …

Rosmarinic acid is a natural polyphenolic compound that is found in different plant species
and used for different medicinal purposes. This study aimed to investigate the chemo …

Cratoxylum formosum Dyer has been used in Southeast Asian countries both for food and
folk medicine. In this study, the leaf extracts of C. formosum were evaluated for anticancer …

Background: Gambogic acid (GA) is a major active ingredient of gamboge, a widely used
traditional Chinese medicine that has been reported to be a potent cytotoxic agent against …