Abstract Background Kisspeptins, encoded by Kiss1, have emerged as essential regulators
of puberty and reproduction by primarily acting on GnRH neurons, via their canonical …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r
gene), have well-established roles in stimulating reproduction via central actions on …

Kisspeptin, encoded by Kiss1 gene expressing neurons in the hypothalamus, is a requisite
for fertility and now appears critical in the regulation of energy balance. Kisspeptin neurons …

Body energy balance and metabolic signals are important modulators of puberty and
reproductive function, so that perturbations of metabolism and energy reserves (ranging …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Kisspeptins, encoded by the Kiss1 gene, and their canonical receptor, GPR54 (also termed
Kiss1R), are unanimously recognised as essential regulators of puberty onset and …

The neurohormonal control of reproduction involves a hierarchical network of central and
peripheral signals in the hypothalamic–pituitary–gonadal (HPG) axis. Development and …

Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene, and their
receptor, GPR54, in the control of reproduction has been a major breakthrough in …

Kisspeptin regulates reproduction via signaling through the receptor, Kiss1r, in GnRH
neurons. However, both kisspeptin and Kiss1r are produced in several peripheral tissues …