Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy
Z Li, H Shen, Y Liu, X Zhou, M Yan, H He, T Zhao… - Genes & Genomics, 2022 - Springer
Background Diabetic nephropathy (DN) is a serious threat to human health, but its
pathogenesis is not fully understood. Otsuka Long-Evans Tokushima Fatty (OLETF) rats are …
pathogenesis is not fully understood. Otsuka Long-Evans Tokushima Fatty (OLETF) rats are …
[HTML][HTML] Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic …
S Nakatani, A Kakehashi, E Ishimura… - Journal of Diabetes …, 2011 - hindawi.com
To evaluate proteins associated with the development of diabetic nephropathy, a major
cause of the end-stage renal disease, we analyzed protein expression in isolated glomeruli …
cause of the end-stage renal disease, we analyzed protein expression in isolated glomeruli …
[HTML][HTML] Transcriptional profile of kidney from type 2 diabetic db/db mice
H Zhang, T Zhao, Z Li, M Yan, H Zhao, B Zhu… - Journal of diabetes …, 2017 - hindawi.com
Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized
by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying …
by progressive glomerular sclerosis and tubulointerstitial fibrosis. However, the underlying …
[HTML][HTML] Dynamic phenotypes and molecular mechanisms to understand the pathogenesis of diabetic nephropathy in two widely used animal models of type 2 …
Y Liu, H Huang, R Gao, Y Liu - Frontiers in cell and developmental …, 2020 - frontiersin.org
Objective We aimed to characterize the pathogenesis of diabetic nephropathy (DN) in two
commonly used type 2 diabetes mellitus (T2DM) animal models and explore the preliminary …
commonly used type 2 diabetes mellitus (T2DM) animal models and explore the preliminary …
Stage-specific quantitative changes in renal and urinary proteome during the progression and development of streptozotocin-induced diabetic nephropathy in rats
Diabetic nephropathy (DN) is a microvascular complication associated with diabetes
causing slow deterioration of kidneys leading to end-stage renal disease. Timely …
causing slow deterioration of kidneys leading to end-stage renal disease. Timely …
Comprehensive analysis of the gene expression profile of the male and female BTBR mice with diabetic nephropathy
R Xue, Y Wang, L Geng, H Xiao, V Kumar, X Lan… - International Journal of …, 2024 - Elsevier
Comprehensive insight into the gender-based gene expression-related omics data in a
rodent model of diabetic nephropathy (DN) is scarce. In the present study, the gender-based …
rodent model of diabetic nephropathy (DN) is scarce. In the present study, the gender-based …
[HTML][HTML] Identification of key genes of human advanced diabetic nephropathy independent of proteinuria by transcriptome analysis
F Cai, X Zhou, Y Jia, W Yao, J Lv, G Liu… - BioMed Research …, 2020 - hindawi.com
Background. Diabetic nephropathy (DN) is the leading cause of ESRD. Emerging evidence
indicated that proteinuria may not be the determinant of renal survival in DN. The aim of the …
indicated that proteinuria may not be the determinant of renal survival in DN. The aim of the …
Molecular genetic approaches for studying the etiology of diabetic nephropathy
DPK Ng, AS Krolewski - Current molecular medicine, 2005 - ingentaconnect.com
A critical challenge faced by clinical nephrologists today is the escalating number of patients
developing end stage renal disease, a major proportion of which is attributed to diabetic …
developing end stage renal disease, a major proportion of which is attributed to diabetic …
Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease
To describe gene expression changes that characterize the development of diabetic
nephropathy, we performed microarray and phenotype analysis on kidneys from db/db mice …
nephropathy, we performed microarray and phenotype analysis on kidneys from db/db mice …
[HTML][HTML] Early renal structural changes and potential biomarkers in diabetic nephropathy
Diabetic nephropathy is one of the most serious microvascular complications of diabetes
mellitus, with increasing prevalence and mortality. Currently, renal function is assessed …
mellitus, with increasing prevalence and mortality. Currently, renal function is assessed …