Resistance to infection is critically dependent on the ability of pattern recognition receptors
to recognize microbial invasion and induce protective immune responses. One such family …

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger
intracellular signaling cascades that initiate and direct innate and adaptive immune …

During the course of fungal infection, pathogen recognition by the innate immune system is
critical to initiate efficient protective immune responses. The primary event that triggers …

Melanins are a class of pigments that are ubiquitous throughout biology. They play
incredibly diverse and important roles ranging from radiation protection to immune defense …

Various C-type lectin receptors (CLRs), including Mincle and Dectin-2, function as pattern
recognition receptors and play a central role in immunity to fungal pathogens. However, the …

Recognition of fungal pathogens by C-type lectin receptor (CLR) dectin-1 on human
dendritic cells is essential for triggering protective antifungal TH 1 and TH 17 immune …

Fungi are the cause of opportunistic infections, predominantly in immunocompromised
individuals although, primary fungal infections can occur in apparently healthy individuals …

Melanin biopigments have been linked to fungal virulence. Aspergillus fumigatus conidia
are melanised and are weakly immunogenic. We show that melanin pigments on the surface …

Highlights•C-type lectin receptors (CLRs) recognize various fungi through carbohydrate-
containing ligands.•Differing CLRs induce distinct immune responses through the same …

Fungi can cause disease in humans, from mucocutaneous to life-threatening systemic
infections. Initiation of antifungal immunity involves fungal recognition by pattern recognition …