[HTML][HTML] HLA associations in classical Hodgkin lymphoma: EBV status matters

X Huang, K Kushekhar, I Nolte, W Kooistra, L Visser… - PloS one, 2012 - journals.plos.org
The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic
factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a …

[HTML][HTML] HLA-A* 02: 07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China

X Huang, B Hepkema, I Nolte, K Kushekhar… - PLoS …, 2012 - journals.plos.org
HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is
unknown whether this protective effect also exists in the Chinese population. We …

Modeling HLA associations with EBV‐positive and‐negative H odgkin lymphoma suggests distinct mechanisms in disease pathogenesis

PCD Johnson, KA McAulay… - … Journal of Cancer, 2015 - Wiley Online Library
HLA genotyping and genome wide association studies provide strong evidence for
associations between Human Leukocyte Antigen (HLA) alleles and classical Hodgkin …

HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV+ Hodgkin lymphoma

M Niens, RF Jarrett, B Hepkema… - Blood, The Journal …, 2007 - ashpublications.org
Previous studies showed that the HLA class I region is associated with Epstein-Barr virus
(EBV)–positive Hodgkin lymphoma (HL) and that HLA-A is the most likely candidate gene in …

Genetic susceptibility to Hodgkin's lymphoma associated with the human leukocyte antigen region

A Diepstra, M Niens, GJ Te Meerman… - European Journal of …, 2005 - Wiley Online Library
Based on the presence of an abundant inflammatory infiltrate, expression of a broad
spectrum of cytokines and the professional antigen presenting phenotype of Hodgkin Reed …

The Human Leukocyte Antigen Class I Region Is Associated with EBV-Positive Hodgkin's Lymphoma: HLA-A and HLA Complex Group 9 Are Putative Candidate …

M Niens, A Van Den Berg, A Diepstra, IM Nolte… - … Biomarkers & Prevention, 2006 - AACR
Various studies have indicated that the human leukocyte antigen (HLA) region is associated
with Hodgkin's lymphoma. We recently showed a specific association of the HLA class I …

HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma

H Hjalgrim, K Rostgaard… - Proceedings of the …, 2010 - National Acad Sciences
A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to
infection with the ubiquitous lymphotropic EBV. The determining factors for development of …

Genetic associations in classical hodgkin lymphoma: a systematic review and insights into susceptibility mechanisms

K Kushekhar, A van den Berg, I Nolte, B Hepkema… - … Biomarkers & Prevention, 2014 - AACR
Both targeted and genome-wide studies have revealed genetic associations for
susceptibility, prognosis, and treatment-induced secondary malignancies and toxicities in …

[HTML][HTML] Expression of HLA class I and HLA class II by tumor cells in Chinese classical Hodgkin lymphoma patients

X Huang, A van den Berg, Z Gao, L Visser, I Nolte… - PLoS …, 2010 - journals.plos.org
Background In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive
classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA …

Multiple Hodgkin lymphoma–associated loci within the HLA region at chromosome 6p21. 3

L Moutsianas, V Enciso-Mora, YP Ma… - Blood, The Journal …, 2011 - ashpublications.org
Since an association between the human leukocyte antigen (HLA) region and Hodgkin
lymphoma (HL) was first reported in 1967, many studies have reported associations …