Purpose This study aimed to investigate the association between circulating soluble Klotho
level and risk of all-cause mortality in chronic kidney disease (CKD) patients using …

Introduction: This study aimed to investigate the relationship between circulating soluble
Klotho concentration and all-cause mortality in individuals with chronic kidney disease …

Background Chronic kidney disease (CKD) and end-stage renal disease (ESKD) are
significant global health challenges associated with progressive kidney dysfunction and …

Objective. The prognostic role of Klotho in patients with chronic kidney disease is still
controversial. Therefore, we performed this meta‐analysis to assess the relationship …

Background: Experimental studies indicate that Klotho deficiency is a pathogenic factor for
CKD-related complications, including cardiovascular disease (CVD). However, the …

Klotho is a single‐pass transmembrane protein predominantly expressed in the kidney. The
extracellular domain of Klotho is subject to ectodomain shedding and is released into the …

Aim: The correlation between soluble Klotho (sKlotho) levels and clinical outcomes remains
inconclusive for patients undergoing maintenance haemodialysis (MHD). We aimed to …

Background and aims Evidence indicates that serum Klotho concentration is associated with
mortality in patients with chronic kidney disease (CKD). However, evidence on this …

Background Chronic kidney disease (CKD) is diagnosed in more than 26 million US people,
which increases the risk of many adverse events. α-Klotho was reported to have potential …

CKD appears to be a condition of soluble klotho deficiency. Despite known associations
between low soluble klotho levels and conditions that promote kidney damage, such as …