Iron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …

The growing problem of bacterial antibiotic resistance makes the discovery and
development of new antibiotics increasingly urgent. Otherwise, we will be forced back to a …

Introduction: The emergence of multidrug-resistant bacterial pathogens has led to a global
public health emergency and novel therapeutic options and drug-delivery systems are …

The emergence of antimicrobial resistance is a significant public health issue worldwide,
particularly for healthcare-associated infections caused by carbapenem-resistant gram …

Antibiotic resistance is a global health concern and a current threat to modern medicine and
society. New strategies for antibiotic drug design and delivery offer a glimmer of hope in a …

The increasing bacterial resistance from antibiotic overuse has fostered the search for novel
antimicrobial strategies. In particular, bacterial systems involving iron (Fe) uptake are …

Iron is an essential micronutrient required for the growth of almost all aerobic organisms; the
iron uptake pathway in bacteria therefore represents a possible target for novel …

Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Most of the iron in a mammalian body is complexed with various proteins. Moreover, in
response to infection, iron availability is reduced in both extracellular and intracellular …

ABSTRACT Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin
conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent …