Carbapenem-resistant Enterobacterales (CRE) remain a significant public health threat,
and, despite recent approvals, new antibiotics are needed. Severe infections caused by …

Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A
challenge for modern medicine will be to discover new antibiotics or strategies to combat …

The outer membrane permeability barrier is an important resistance factor of bacterial
pathogens. In combination with drug inactivating enzymes, target alteration and efflux, it can …

Siderophores (from the Greek:“iron carriers”) are defined as relatively low molecular weight,
ferric ion specific chelating agents elaborated by bacteria and fungi growing under low iron …

The possession of specialized iron transport systems may be crucial for bacteria to override
the iron limitation imposed by the host or the environment. One of the most commonly found …

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic
microorganisms and their hosts. It is also a pivotal component of the innate immune …

Cefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent in vitro activity
and in vivo efficacy against most gram-negative bacteria, including carbapenem-resistant …

In Gram-negative bacteria an iron-deficient state is required for both induction of desferri-
siderophores and overproduction of the cognate outer membrane receptor proteins. Thus …

Although a stimulating review by JB Neilands in 1957 [1] correctly identified the
physiological function of certain microbial ferric chelators, it was in 1973 that Charles …

Publisher Summary This chapter discusses bacterial iron metabolism in infection and
immunity. The injection of iron compounds can enhance the virulence of certain bacteria …