Ketamine has been widely used as an analgesic and produces dissociative anesthetic
effects. The antinociceptive effects of ketamine have been studied, but the involvement of …

The participation of endocannabinoids in central and peripheral antinociception induced by
several compounds has been shown by our group. In this study, we investigated the effect of …

BACKGROUND: Cannabinoid agonists induce norepinephrine release in central, spinal,
and peripheral sites. Previous studies suggest an interaction between the cannabinoid and …

AIMS: The effects of several potassium (K+) channel blockers were studied to determine
which K+ channels are involved in peripheral antinociception induced by the cannabinoid …

Background The studies on the mechanisms of ketamine antinociception have led to
conflicting results. In this study, the authors investigated the contribution of supraspinal …

Central antinociceptive effects of cannabinoids have been well documented. However,
relatively little is known about the peripheral effects of the cannabinoids on inflammation. In …

ABSTRACT OBJECTIVE: In pain management, alternative medications are necessary due to
the development of tolerance to traditional opioid analgesics. Literature data suggest that N …

In the rat, antinociception of supraspinal origin is observed in response to administration of
cocaine or an antagonist of the NMDA receptor for glutamate. The current study was …

Historically, the evidence for cannabinoids acting as analgesics has been mostly anecdotal.
Recently, studies utilizing animal models have indicated that cannabinoids produce …

This study assessed the effects of two N-acylethanolamides in established rat models of
visceral and somatic inflammatory pain.(1) The therapeutic effects of the cannabinoid …