Many vertebrate organs are derived from monolayered epithelia that undergo
morphogenesis to acquire their shape. Whereas asymmetric left/right gene expression …

Embryonic heart formation requires the union of bilateral populations of cardiomyocytes and
their reorganization into a simple tube. Little is known about the morphogenetic mechanisms …

The Nodal signaling pathway plays a conserved role in determining left-sided identity in
vertebrates with this early left-right (L/R) patterning influencing the asymmetric development …

We have used high-resolution 4D imaging of cardiac progenitor cells (CPCs) in zebrafish to
investigate the earliest left-right asymmetric movements during cardiac morphogenesis …

Although vertebrates appear bilaterally symmetric on the outside, various internal organs,
including the heart, are asymmetric with respect to their position and/or their orientation …

Developing organs acquire a specific three-dimensional form that ensures their normal
function. Cardiac function, for example, depends upon properly shaped chambers that …

Amongst animal species, there is enormous variation in the size and complexity of the heart,
ranging from the simple one-chambered heart of Ciona intestinalis to the complex four …

Organogenesis is a dynamic process involving multiple phases of pattern formation and
morphogenesis. For example, heart formation involves the specification and differentiation of …

The heart is laterally asymmetric. Not only is it positioned on the left side of the body but the
organ itself is asymmetric. This patterning occurs across scales: at the organism level …

Building a left-right (LR) asymmetric organ requires asymmetric information. This comes
from various sources, including asymmetries in embryo-scale genetic cascades (including …