Heart failure (HF) is a complex chronic clinical syndrome. Energy deficit is considered to be
a key contributor to the development of both cardiac and skeletal myopathy. In HF, several …

This review focuses on the evidence accumulated in humans and animal models to the
effect that mitochondria are key players in the progression of heart failure (HF). Mitochondria …

The mitochondrion serves a critical role as a platform for energy transduction, signaling, and
cell death pathways relevant to common diseases of the myocardium such as heart failure …

A number of observations have shown that mitochondria are at the center of the
pathophysiology of the failing heart and mitochondrial-based oxidative stress (OS) …

Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

Abstract Purpose of Review We review therapeutic approaches aimed at restoring function
of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling …

Cardiac mitochondria, the main source of energy as well as free radicals, are vital
organelles for normal functioning of the heart. Mitochondrial number, structure, turnover and …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

Normal cardiac function requires high and continuous supply with ATP. As mitochondria are
the major source of ATP production, it is apparent that mitochondrial function and cardiac …

Patients with heart failure (HF) usually present with skeletal muscle diseases of varying
severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or …