Nicotine and nicotinic agonists such as acetylcholine, methylcarbamyl choline, and cytisine
at nanomolar concentrations bind to a separate group of central nervous system (CNS) …

Multiple nicotinic receptors seem to exist in brain as revealed by neurophysiological,
neurochemical, molecular and immunological studies. The mechanisms for their …

Neuronal nicotinic cholinergic receptors mediate the actions of acetylcholine in ganglia and
the CNS. These receptors are pentameric proteins formed from combinations of 12 different …

Advances in the understanding of the structure, function, and distribution of central nervous
system (CNS) nicotinic receptors has provided the impetus for new studies examining the …

CNS nicotinic acetylcholine receptors are a family of ligand-gated cation channels that allow
the passage of calcium ions. They are structurally and functionally distinct from nicotinic …

A review of studies on nicotinic cholinergic receptors in human brain is presented. The
paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies …

The distribution in the rat brain of high affinity nicotinic heteromeric acetylcholine receptors
and of low affinity nicotinic, α7-containing, homomeric receptors was studied using in vitro …

Neuronal nicotinic acetylcholine receptors mediate nicotine's diverse effects on the brain,
spinal cord and autonomic nervous system. These receptors are composed of α and β …

Neuronal nicotinic receptors are key molecules for signal transduction in a number of
neuronal pathways. They are widely distributed in the brain and are known to be involved in …

The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled
by acetylcholine. It is a key molecule in the chemical communication between nerve cells …