The discovery that mammalian brain expresses the mRNAs for nine different nicotinic
cholinergic receptor subunits (α2–α7, β2–β4) that form functional receptors when expressed …

MEETING REPORT respond to nicotine and so, unlike their wild-type counterparts, do not
learn intravenous nicotine self-administration. NNRs also seem to be involved in …

The role of the β3 and β4 subunits of the nicotinic acetylcholine receptor in brain is still
unclear. We investigated nicotinic receptor structure with antibodies directed against unique …

Brain nicotinic receptors were studied in the frontal cortex, temporal cortex, hippocampus
and caudate nucleus in patients with Parkinson's disease (PD), Alzheimer's disease (AD) …

The cholinergic system, particularly the cortically projecting neurons situated in the basal
forebrain, is clearly involved in a variety of human disorders associated with dementia …

Neuronal nicotinic receptors (nAChRs) are a heterogeneous family of ion channels
differently expressed in the nervous system where, by responding to the endogenous …

Chronic exposure to nicotine has been shown to increase binding to high affinity nicotinic
cholinergic receptors in rat brain, but the effect of this treatment on the low affinity α7 …

Progress in understanding the CNS nicotinic acetylcholine receptor (nA ChR) has been
hindered by the absence o fan antagonist that both biochemically binds receptor sites and …

J. Neurochem.(2011) 119, 153–164. Abstract Nicotine increases the number of neuronal
nicotinic acetylcholine receptors (nAChRs) in brain. This study investigated the effects of …

Neuronal nicotinic receptors are involved in a wide variety of diseases affecting both the
nervous system and non-neuronal tissues. Diseases with neuronal acetylcholine receptor …