Enhanced oral bioavailability of 10-hydroxycamptothecin through the use of poly (n-butyl cyanoacrylate) nanospheres

X Jin, S Asghar, X Zhu, Z Chen, J Liu, Y Li… - Drug Development …, 2017 - Taylor & Francis
The article describes the preparation, physicochemical characterization, drug release, and
in vivo behavior of 10-hydroxycamptothecin-loaded poly (n-butyl cyanoacrylate)(PBCA) …

In vitro and in vivo evaluation of 10-hydroxycamptothecin-loaded poly (n-butyl cyanoacrylate) nanoparticles prepared by miniemulsion polymerization

X Jin, S Asghar, X Zhu, Z Chen, C Tian, L Yin… - Colloids and Surfaces B …, 2018 - Elsevier
Abstract In this paper, 10-hydroxycamptothecin (HCPT)-loaded poly (n-butyl cyanoacrylate)
nanoparticles (HCPT-PBCA-NPs) co-modified with polysorbate 80, soybean phospholipids …

Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles

L Yang, F Cui, D Cun, A Tao, K Shi, W Lin - International journal of …, 2007 - Elsevier
10-Hydroxycamptothecin (HCPT) is insoluble in both water and physiological acceptable
organic solvents and tends to change into its carboxylate form, which shows minimal …

Study on liver targeting and sustained release hydroxycamptothecin polybutylcyanoacrylate nanoparticles

ZR Zhang, W Lu - Yao xue xue bao= Acta Pharmaceutica Sinica, 1997 - europepmc.org
The liver targeting and sustained release hydroxycamptothecin polybutylcyanoacrylate
nanoparticles (HCPT-PBCA-NP) which were wrapped up with ployvinylpyrrolidone (PVP) …

Sustained-release hydroxycamptothecin polybutylcyanoacrylate nanoparticles as a liver targeting drug delivery system

X Sun, F Wu, W Lu, ZR Zhang - Die Pharmazie-An International …, 2004 - ingentaconnect.com
Sustained release hydroxycamptothecin polybutylcyanoacrylate nanoparticles (HCPT-PBCA-
NP) associated with polybutylpyrolidone (PVP) for liver targeting were prepared by the …

Preparation and properties of hydroxycamptothecin-loaded nanoparticles made of amphiphilic copolymer and normal polymer

J Wang, R Wang, LB Li - Journal of colloid and interface science, 2009 - Elsevier
Stabilized micelle structure nanoparticles were prepared using Pluronic F127 and poly
(butylcyanoacrylate)(PBCA). To increase the drug loading of nanoparticles, d-α-tocopheryl …

Preparation and characterization of 10-hydroxycamptothecin loaded nanostructured lipid carriers

K Liu, J Sun, Y Wang, Y He, K Gao… - Drug development and …, 2008 - Taylor & Francis
Two types of 10-hydroxycamptothecin (10-HCPT) loaded nanostructured lipid carriers (NLC-
F 68 and NLC-Brij 35) intended for use as the alternative formulation of 10-HCPT for …

A novel composite hydrogel based on chitosan and inorganic phosphate for local drug delivery of camptothecin nanocolloids

XY Li, XY Kong, J Zhang, YJ Wang… - Journal of …, 2011 - Wiley Online Library
In attempt to overcome the problem of low water solubility and severe toxicity of
camptothecin (CPT) after intravenous administration, a novel drug carrier system based on …

Development of a chemically stable 10-hydroxycamptothecin nanosuspensions

X Pu, J Sun, Y Wang, Y Wang, X Liu, P Zhang… - International Journal of …, 2009 - Elsevier
The purpose of this study was to prepare and characterize nanosuspensions loading the
active lactone form of 10-hydroxycamptothecin (10-HCPT). Nanosuspensions were …

Pharmaceutical nanotechnology: A novel composite hydrogel based on chitosan and inorganic phosphate for local drug delivery of camptothecin nanocolloids

XY Li, XY Kong, J Zhang, YJ Wang, YJ Wang… - Journal of …, 2011 - Elsevier
In attempt to overcome the problem of low water solubility and severe toxicity of
camptothecin (CPT) after intravenous administration, a novel drug carrier system based on …