Load and lock: the molecular mechanisms of B‐lymphocyte commitment

S Zandi, D Bryder, M Sigvardsson - Immunological reviews, 2010 - Wiley Online Library
The maturation of B‐lymphoid cells from hematopoietic stem cells in the bone marrow is a
complex process under control of interplay between extrinsic and intrinsic factors. In addition …

Role of transcription factors in commitment and differentiation of early B lymphoid cells

S Roessler, R Grosschedl - Seminars in immunology, 2006 - Elsevier
B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted
into antibody-producing plasma cells. B cell differentiation involves multiple steps, including …

B-cell commitment: deciding on the players

RR Hardy - Current opinion in immunology, 2003 - Elsevier
Considerable progress has been made over the past few years in determining the key
molecular players that regulate the commitment and development of early B-lineage cells in …

Molecular regulation of differentiation in early B-lymphocyte development

M Sigvardsson - International journal of molecular sciences, 2018 - mdpi.com
B-lymphocyte differentiation is one of the best understood developmental pathways in the
hematopoietic system. Our understanding of the developmental trajectories linking the …

Transcriptional regulation of lymphocyte development

S Dias, W Xu, S McGregor, B Kee - Current opinion in genetics & …, 2008 - Elsevier
B lymphocytes and T lymphocytes develop from hematopoietic stem cells through a series of
intermediates with progressively decreased lineage differentiation potential. Differentiation …

Epigenetic events during B lymphocyte development

M Parra - Epigenetics, 2009 - Taylor & Francis
The generation of B cells is the result of several cell lineage choices, cell commitment and
differentiation. These cellular transitions take place in a stepwise manner and are regulated …

B-lymphocyte commitment: identifying the point of no return

E Welinder, J Åhsberg, M Sigvardsson - Seminars in immunology, 2011 - Elsevier
Even though B-lymphocyte development is one of the best understood models for cell
differentiation in the hematopoetic system, recent advances in cell sorting and functional …

Genetic networks that regulate B lymphopoiesis

KL Medina, H Singh - Current opinion in hematology, 2005 - journals.lww.com
Genetic networks that regulate B lymphopoiesis : Current Opinion in Hematology Genetic
networks that regulate B lymphopoiesis : Current Opinion in Hematology Log in or Register …

Regulation of lineage commitment during lymphocyte development

FJT Staal, HC Clevers - International Reviews of Immunology, 2001 - Taylor & Francis
B and T lymphocytes develop from pluripotent hematopoietic stem cells through a complex
differentiation pathway involving many different phenotypically distinct subpopulations [11 …

Complementary regulation of early B-lymphoid differentiation by genetic and epigenetic mechanisms

T Yokota, T Sudo, T Ishibashi, Y Doi, M Ichii… - International journal of …, 2013 - Springer
Although B lymphopoiesis is one of the best-defined paradigms in cell differentiation, our
knowledge of the regulatory mechanisms underlying its earliest processes, in which …