Early-onset cancer in the gastrointestinal tract is on the rise—evidence and implications

I Ben-Aharon, HWM van Laarhoven, E Fontana… - Cancer discovery, 2023 - AACR
Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

K Mima, T Hamada, K Inamura, H Baba, T Ugai… - Gut …, 2023 - Taylor & Francis
Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Rising incidence of early-onset colorectal cancer—A call to action

N Akimoto, T Ugai, R Zhong, T Hamada… - Nature reviews Clinical …, 2021 - nature.com
The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

Colorectal cancer in young adults

A Venugopal, EM Stoffel - Current treatment options in gastroenterology, 2019 - Springer
Purpose of review Routine screening for colorectal cancer (CRC) in adults> 50 years of age
has led to overall reductions in CRC incidence and CRC-related mortality. Yet CRC …

The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection

SG Patel, JJ Karlitz, T Yen, CH Lieu… - The lancet …, 2022 - thelancet.com
The incidence of early-onset colorectal—ie, colorectal cancer cancer diagnosed in patients
under the age of 50 years—has been increasing around the world. This Series paper …

Early-onset colorectal cancer: initial clues and current views

LJ Hofseth, JR Hebert, A Chanda, H Chen… - Nature reviews …, 2020 - nature.com
Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

The role of diet and lifestyle in early-onset colorectal cancer: a systematic review

M Puzzono, A Mannucci, S Grannò, RA Zuppardo… - Cancers, 2021 - mdpi.com
Simple Summary This systematic review sifted through the exogenous dietary and lifestyle
risk factors associated with early-onset colorectal cancer, going through the putative …

The rising incidence of younger patients with colorectal cancer: questions about screening, biology, and treatment

LC Connell, JM Mota, MI Braghiroli, PM Hoff - Current treatment options in …, 2017 - Springer
Opinion statement Colorectal cancer (CRC) is the third leading cancer diagnosed globally
and an important cause of cancer-related mortality. Of interest, while we have witnessed a …

Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults

EM Stoffel, CC Murphy - Gastroenterology, 2020 - Elsevier
In contrast to the decreasing incidence of colorectal cancer (CRC) in older populations, the
incidence has nearly doubled in younger adults since the early 1990s. Approximately 1 in …

[HTML][HTML] Young-onset colorectal cancer: A review

JZ Done, SH Fang - World journal of gastrointestinal oncology, 2021 - ncbi.nlm.nih.gov
Despite the general decrease in overall incidence of colorectal cancer since the early
1990s, the incidence of colorectal cancer in patients less than 50 years old has nearly …