Detecting axonal injury in individual patients after traumatic brain injury

AE Jolly, M Bălăeţ, A Azor, D Friedland, S Sandrone… - Brain, 2021 - academic.oup.com
Poor outcomes after traumatic brain injury (TBI) are common yet remain difficult to predict.
Diffuse axonal injury is important for outcomes, but its assessment remains limited in the …

[HTML][HTML] Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome

V Newcombe, D Chatfield, J Outtrim, S Vowler… - PloS one, 2011 - journals.plos.org
Background Traumatic brain injury is a major cause of morbidity and mortality worldwide.
Ameliorating the neurocognitive and physical deficits that accompany traumatic brain injury …

Analysis of acute traumatic axonal injury using diffusion tensor imaging

VFJ Newcombe, GB Williams, J Nortje… - British journal of …, 2007 - Taylor & Francis
Traumatic axonal injury (TAI) contributes significantly to mortality and morbidity following
traumatic brain injury (TBI), but is poorly characterized by conventional imaging techniques …

Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study

JJ Bazarian, J Zhong, B Blyth, T Zhu, V Kavcic… - Journal of …, 2007 - liebertpub.com
The goal of the current investigation was to detect clinically important axonal damage in
cerebral white matter after mild traumatic brain injury (TBI) using diffusion tensor imaging …

Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury

TAGM Huisman, LH Schwamm… - American Journal …, 2004 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Multiple biomarkers are used to quantify the severity of
traumatic brain injury (TBI) and to predict outcome. Few are satisfactory. CT and …

Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury

RR Benson, SA Meda, S Vasudevan, Z Kou… - Journal of …, 2007 - liebertpub.com
Conventional clinical neuroimaging is insensitive to axonal injury in traumatic brain injury
(TBI). Immunocytochemical staining reveals changes to axonal morphology within hours …

Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging

J Xu, IA Rasmussen, J Lagopoulos… - Journal of …, 2007 - liebertpub.com
Traumatic brain injury (TBI) is the most common cause of death and disability in young
people. The functional outcome in patients with TBI cannot be explained by focal pathology …

[HTML][HTML] Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis

BL Edlow, WA Copen, S Izzy, K Bakhadirov… - BMC neurology, 2016 - Springer
Background Diffusion tensor imaging (DTI) may have prognostic utility in patients with
traumatic brain injury (TBI), but the optimal timing of DTI data acquisition is unknown …

Diffuse axonal injury predicts neurodegeneration after moderate–severe traumatic brain injury

NSN Graham, A Jolly, K Zimmerman, NJ Bourke… - Brain, 2020 - academic.oup.com
Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such
as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models …

Robust detection of traumatic axonal injury in individual mild traumatic brain injury patients: intersubject variation, change over time and bidirectional changes in …

ML Lipton, N Kim, YK Park, MB Hulkower… - Brain imaging and …, 2012 - Springer
To identify and characterize otherwise occult inter-individual spatial variation of white matter
abnormalities across mild traumatic brain injury (mTBI) patients. After informed consent and …