The locus coeruleus (LC) is the site where tau accumulation is preferentially observed
pathologically in Alzheimer's disease (AD) patients, but the changes in gray matter co …

Recent studies have demonstrated the pivotal role of locus coeruleus (LC) and salience
network (SN) resting state functional connectivity (rsFC) changes in the early stage of …

Animal and human imaging research reported that the presence of cortical Alzheimer's
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …

The locus coeruleus (LC) is one of the earliest sites of tau pathology, making it a key
structure in early Alzheimer's disease (AD) progression. As the primary source of …

Background Alzheimer's disease (AD) is one of most prevalent neurodegenerative diseases
worldwide and characterized by cognitive decline and brain structure atrophy. While studies …

Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with
tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC‐I) on 3T MRI to …

Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …

Alzheimer's disease (AD) has a long neuropathological accumulation phase before the
onset of dementia. Such AD neuropathological deposition between neurons impairs the …

Background Autopsy work indicates that the widely-projecting noradrenergic pontine locus
coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a …

Background Both subjective cognitive decline (SCD) and amnestic mild cognitive
impairment (aMCI) have a high risk of progression to Alzheimer's disease (AD). While most …