Brain inflammaging is considered as one of the underlying factors of neurodegenerative
diseases. The present study aimed to investigate the effects of melatonin, an endogenous …

Oxidative stress is defined as a disturbance in the prooxidant–antioxidant balance, leading
to potential cell damage. Reactive oxygen species such as superoxide radicals, hydroxyl …

OBJECTIVE: To investigate the roles and underlying mechanisms of melatonin in oxygen-
glucose deprivation/reoxygenation (OGD/R)-insulted SH SY5Y cells. MATERIALS AND …

Melatonin has been known to affect a variety of astrocytes functions in many neurological
disorders but its mechanism of action on neuroinflammatory cascade and alpha-7 nicotinic …

Melatonin has been shown to down-regulate inflammatory responses and provide
neuroprotection. However, the mechanisms underlying the anti-inflammatory properties of …

Many obstacles compromise the efficacy of bone marrow mesenchymal stem cells (BM-
MSCs) by inducing apoptosis in the grafted BM-MSCs. The current study investigates the …

Melatonin is synthesized mainly in pineal gland. It has been suggested that melatonin has
proven antioxidant effects and protective effects against neuronal cell degeneration. There …

Neuroprotective effects of melatonin against oxidative stress‐induced neuronal cell
degeneration in human SH‐SY5Y neuroblastoma cells were investigated in this report. The …

Melatonin (N‐acetyl‐5‐methoxytryptamine), an indole hormone, is the chief secretory
product of the pineal gland and is an efficient free radical scavenger and antioxidant, both in …

Stroke and Alzheimer's disease (AD) are prevalent age-related diseases; however, the
relationship between these two diseases remains unclear. In this study, we aimed to …