The importance of the central melanocortin system in the regulation of energy balance is
highlighted by studies in transgenic animals and humans with defects in this system. Mice …

The melanocortins, a family of peptides produced from the post-translational processing of
pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of …

Proopiomelanocortin (POMC) is expressed in the arcuate nucleus of the hypothalamus
(ARC) and the commissural nucleus of the solitary tract (cNTS). Post‐translational …

Neurons of the arcuate nucleus of the hypothalamus (ARH) appear to be sites of
convergence of central and peripheral signals of energy stores, and profoundly modulate …

▪ Abstract Animals have developed highly adaptive and redundant mechanisms to maintain
energy balance by matching caloric intake to caloric expenditure. Recent evidence has …

The melanocortin peptides derived from pro-opiomelanocortin (POMC) were originally
understood in terms of the biological actions of α-melanocyte-stimulating hormone (α-MSH) …

The melanocortin system plays a critical role in the central regulation of food intake and
energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC) …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Obesity is a significant health problem owing to increased risk for diabetes and
cardiovascular disease, and several lines of evidence suggest that alterations in the central …

Following the cloning of the melanocortin receptor and agouti protein genes, a model was
developed for the central melanocortin system with respect to the regulation of energy and …