Following the cloning of the melanocortin receptor and agouti protein genes, a model was
developed for the central melanocortin system with respect to the regulation of energy and …

Identifying the role of the melanocortin system in regulating energy homeostasis has relied
on both genetic and pharmacological studies. The key findings included 1) that the coat …

Melanocortin peptides, derived from POMC (pro-opiomelanocortin) are produced in the ARH
(arcuate nucleus of the hypothalamus) neurons and the neurons in the commissural NTS …

The central melanocortin system plays a key role in the regulation of energy homeostasis.
Neurons containing the peptide precursor proopiomelanocortin (POMC) are found at two …

Five G-protein-coupled melanocortin receptors (MC1–MC5) are expressed in mammalian
tissues. The melanocortin receptors support diverse physiological functions, including the …

The central melanocortin system has been demonstrated to play a pivotal role in energy
homeostasis. Genetic disruption of this system causes obesity in both humans and mice …

The peptide products of the pro-opiomelanocortin (POMC) gene have established roles in
the control of physiological processes as diverse as adrenal steroidogenesis, skin …

The melanocortin-4 receptor (MC4R), a centrally expressed G protein–coupled receptor
(GPCR), is essential for the maintenance of long-term energy balance in humans. Mutations …

The neural melanocortin receptors, melanocortin-3 and-4 receptors (MC3R and MC4R),
have been shown to regulate different aspects of energy homeostasis in rodents. Human …

Abstract The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis,
including both energy intake and energy expenditure. It mediates the actions of a number of …