Mutations in the melanocortin 4 receptor gene (MC4R) are the most common cause of
monogenic human obesity. As part of our ongoing project entitled 'Turkish Obesity Genome …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition,
natriuresis, immune function, and entrainment of circadian rhythms to nutrient intake. MC3Rs …

The central melanocortin 4 receptor (MC4R) plays a critical role in energy homeostasis,
although little is known regarding its role in the regulation of adaptive thermogenesis of …

Kennedy hypothesized nearly 50 y ago that negative feedback regulation of body fat stores
involves hormones that circulate in proportion to adiposity and enter the brain, where they …

The alarming increase in the incidence of obesity and obesity-associated disorders makes
the etiology of obesity a widely studied topic today. As opposed to 'homeostatic feeding' …

A number of different neuropeptides exert powerful concerted controls on feeding behavior
and energy balance, most of them being produced in hypothalamic neuronal networks …

The central melanocortin (MC) system has been demonstrated to act downstream of leptin in
the regulation of body weight. The system comprises α-MSH, which acts as agonist, and …

The hypothalamus regulates many aspects of energy homeostasis, adjusting both the drive
to eat and the expenditure of energy in response to a wide range of nutritional and other …

The hypothalamic melanocortin system is crucial for the control of appetite and body weight.
Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic …