Adaptive thermogenesis represents one of the important homeostatic mechanisms by which
the body maintains appropriate levels of stored energy and its core temperature …

Melanocortin-4 receptor (Mc4r)-null mice exhibit late-onset obesity. To determine whether
aberrant metabolism contributes to the obesity, food consumption by Mc4r-null mice was …

Evidence that melanocortin obesity syndrome could occur in humans came from the astute
recognition of an agouti mouse–like syndrome in two families, resulting from null mutations …

Melanocortin peptides (adrenocorticotropin (ACTH), α-, β-, and γ-melanocyte stimulating
hormone (MSH), and fragments thereof) derived from proopiomelanocortin (POMC) have a …

The central melanocortin system has emerged as a potential regulator of food intake. This
action of melanocortins appears to occur through intrahypothalamic, melanocortin …

Defective melanocortin signaling causes hyperphagic obesity in humans and the
melanocortin-4 receptor knockout mouse (MC4R−/−). The human disease most commonly …

Studies using nonselective agonists and antagonists of melanocortin-3 receptor (MC3R)
and MC4R point to the importance of the CNS melanocortin system in the control of food …

Mutations in the melanocortin-4 receptor (MC4R) are associated with obesity. The obesity
syndrome observed in humans with MC4R haploinsufficiency is similar to that observed in …

In response to moderately increased dietary fat content, melanocortin-4 receptor-null mutant
(MC4R−/−) mice exhibit hyperphagia and accelerated weight gain compared to wild-type …

The central melanocortin system regulates body energy homeostasis including the
melanocortin‐4 receptor (MC4R). The lateral hypothalamic area (LHA) receives dense …