V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound
Binding to the host cell receptors CD4 and CCR5/CXCR4 triggers conformational changes
in the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer that …
in the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer that …
Activation and inactivation of primary human immunodeficiency virus envelope glycoprotein trimers by CD4-mimetic compounds
N Madani, AM Princiotto, C Zhao… - Journal of …, 2017 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the viral
envelope glycoproteins (Env), a trimer of three gp120 exterior glycoproteins, and three gp41 …
envelope glycoproteins (Env), a trimer of three gp120 exterior glycoproteins, and three gp41 …
[HTML][HTML] Subtype-specific conservation of isoleucine 309 in the envelope V3 domain is linked to immune evasion in subtype C HIV-1 infection
The V3 region of the HIV-1 envelope (Env) glycoprotein gp120 is a key functional domain
yet it exhibits distinct mutational patterns across subtypes. Here an invariant residue (Ile …
yet it exhibits distinct mutational patterns across subtypes. Here an invariant residue (Ile …
Enhancement of CD4 Binding, Host Cell Entry, and Sensitivity to CD4bs Antibody Inhibition Conferred by a Natural but Rare Polymorphism in the HIV-1 Envelope
AN Ratcliff, CM Venner, AS Olabode, J Knapp… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT A rare but natural polymorphism in the HIV-1 envelope (Env) glycoprotein,
lysine at position 425 was selected as a mutation conferring resistance to maraviroc (MVC) …
lysine at position 425 was selected as a mutation conferring resistance to maraviroc (MVC) …
[HTML][HTML] V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies
MM Laakso, FH Lee, B Haggarty, C Agrawal… - PLoS …, 2007 - journals.plos.org
The V1/V2 region and the V3 loop of the human immunodeficiency virus type I (HIV-1)
envelope (Env) protein are targets for neutralizing antibodies and also play an important …
envelope (Env) protein are targets for neutralizing antibodies and also play an important …
Influence of the envelope gp120 Phe 43 cavity on HIV-1 sensitivity to antibody-dependent cell-mediated cytotoxicity responses
ABSTRACT HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound
conformation on their surface are preferentially targeted by antibody-dependent cellular …
conformation on their surface are preferentially targeted by antibody-dependent cellular …
Cryptic nature of a conserved, CD4-inducible V3 loop neutralization epitope in the native envelope glycoprotein oligomer of CCR5-restricted, but not CXCR4-using …
The external subunit of the human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein (Env), gp120, contains conserved regions that mediate sequential interactions …
glycoprotein (Env), gp120, contains conserved regions that mediate sequential interactions …
The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptors
SE Malenbaum, D Yang, L Cavacini, M Posner… - Journal of …, 2000 - Am Soc Microbiol
We investigated the underlying mechanism by which the highly conserved N-terminal V3
loop glycan of gp120 conferred resistance to neutralization of human immunodeficiency …
loop glycan of gp120 conferred resistance to neutralization of human immunodeficiency …
[HTML][HTML] Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site
Y Feng, K McKee, K Tran, S O'Dell, SD Schmidt… - Journal of Biological …, 2012 - ASBMB
HIV-1 gp120 binds the primary receptor CD4. Recently, a plethora of broadly neutralizing
antibodies to the gp120 CD4-binding site (CD4bs) validated this region as a target for …
antibodies to the gp120 CD4-binding site (CD4bs) validated this region as a target for …