Most cancer-related deaths are a result of metastasis, and thus the importance of this
process as a target of therapy cannot be understated. By asking 'how can we effectively treat …

Metastasis remains the major driver of mortality in patients with cancer. Our growing body of
knowledge regarding this process provides the basis for the development of molecularly …

Metastatic disease is responsible for 90% of death from solid tumors. However, only a
minority of metastasis-specific targets has been exploited therapeutically, and effective …

As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our
effort to fight cancer as a life-threatening disease. The explosive growth of metastasis …

Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

The suppression of cancer metastasis is an urgent therapeutic need. Yet, most existing
drugs inhibit only cancer cell proliferation. Historically, the reason is the much later …

Metastases that are resistant to conventional therapy are the major cause of death from
cancer. In most patients, metastasis has already occurred by the time of diagnosis. Thus, the …

Tumour metastasis, the movement of tumour cells from a primary site to progressively
colonize distant organs, is a major contributor to the deaths of cancer patients. Therapeutic …

Metastasis is the leading cause of cancer death. The metastatic cascade is a complex yet
inefficient process that we have only begun to understand in recent years. Several of the …

Despite recent therapeutic advances in cancer treatment, metastasis remains the principal
cause of cancer death. Recent work has uncovered the unique biology of metastasis …