Abstract Phosphatidylinositol 4, 5-bisphosphate (PI4, 5P 2) is a lipid messenger that
regulates a wide variety of cellular functions. The majority of cellular PI4, 5P 2 is generated …

Phosphatidylinositol 4, 5 bisphosphate (PIP2) is a key lipid messenger for regulation of cell
migration. PIP2 modulates many effectors, but the specificity of PIP2 signalling can be …

Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is
mediated by a limited repertoire of structurally defined, lipid recognition domains. We …

IQGAP1 is a multidomain scaffold protein that coordinates the direction and impact of
multiple signaling pathways by scaffolding its various binding partners. However, the spatial …

Despite being one of the most studied signalling pathways, precisely how phospholipid
synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The …

Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger
phosphatidylinositol 4, 5-bisphosphate (PI4, 5P 2) that controls essentially all aspects of …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP 2) is a membrane bound lipid molecule
with capabilities to affect a wide array of signaling pathways to regulate very different cellular …

Epidermal growth factor receptor (EGFR) and its downstream phosphoinositide 3-kinase
(PI3K) pathway are commonly deregulated in cancer. Recently, we have shown that the IQ …

Generation of the lipid messenger phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns (3, 4, 5)
P3) is crucial for development, cell growth and survival, and motility, and it becomes …

Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …