The design of pharmaceutical crystallization processes is a challenging engineering
problem because of the specific and versatile quality requirements of the end-product …

Prediction and control of the product properties in crystallization processes are practical
challenges in the pharmaceutical industry. Effective crystallization process design and …

Abstract l-ascorbic acid is synthetized in large industrial scale from glucose and marketed as
an immune system strengthening agent and anti-oxidant ingredient. The overall yield of …

Precompetitive collaborations on new enabling technologies for research and development
are becoming popular among pharmaceutical companies. The Enabling Technologies …

Purity is a critical quality attribute for both pharmaceutical and biopharmaceutical products.
The presence of impurities (solvents, salts, or byproducts of the synthetic path) in drugs can …

A systematic digital design framework for the development of a digital twin of a continuous
crystallization process was presented using the model compound, diphenhydramine …

Using process modeling to understand process dynamics and potentially explore the design
space of a crystallization process is difficult because of its complex nature with many factors …

A cooling profile for a seeded pharmaceutical crystallization designed to achieve a desired
mean crystal size is found by minimizing the batch operating time subject to a crystallization …

The simultaneous control of crystal size and shape is particularly important in
pharmaceutical crystallization processes. These two quantities not only influence the …

Crystallization of active pharmaceutical ingredients (API) is one of the most important and
complex multiphase engineering operations in pharmaceutical manufacturing industry. The …