Vascular cognitive impairment: pathophysiological mechanisms, insights into structural basis, and perspectives in specific treatments

VA Parfenov, OD Ostroumova… - Neuropsychiatric …, 2019 - Taylor & Francis
Vascular cognitive impairment (VCI) and vascular dementia are the most common forms of
cognitive disorder associated with cerebrovascular disease and related to increased …

[HTML][HTML] The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

C Iadecola - Acta neuropathologica, 2010 - Springer
There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

Biomarkers related to endothelial dysfunction and vascular cognitive impairment: a systematic review

RK Martins-Filho, MC Zotin, G Rodrigues… - Dementia and Geriatric …, 2021 - karger.com
Introduction: The damage in the endothelium and the neurovascular unit appears to play a
key role in the pathogenesis of vascular cognitive impairment (VCI). Although there have …

Pathogenesis and treatment of vascular cognitive impairment

KA Jellinger - Neurodegenerative disease management, 2014 - Future Medicine
Vascular cognitive impairment (VCI) defines a continuum of disorders ranging from mild
cognitive impairment to full-blown dementia, attributable to cerebrovascular causes. Major …

Vascular cognitive impairment: biomarkers in diagnosis and molecular targets in therapy

GA Rosenberg - Journal of Cerebral Blood Flow & …, 2016 - journals.sagepub.com
The Editors of JCBFM have decided to focus a special issue on aspects of vascular cognitive
impairment (VCI) and the role of vascular disease on other dementias to advance this …

[HTML][HTML] Update on the neurobiology of vascular cognitive impairment: from lab to clinic

L Vinciguerra, G Lanza, V Puglisi, F Fisicaro… - International journal of …, 2020 - mdpi.com
In the last years, there has been a significant growth in the literature exploring the
pathophysiology of vascular cognitive impairment (VCI). As an “umbrella term” …

[HTML][HTML] Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease

A Levit, V Hachinski, SN Whitehead - Geroscience, 2020 - Springer
Executive dysfunction is the most important predictor for loss of independence in dementia.
As executive function involves the coordination of distributed cerebral functions, executive …

[HTML][HTML] Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis

O Shabir, J Berwick, SE Francis - BMC neuroscience, 2018 - Springer
Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences …

[HTML][HTML] Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle

A Popa-Wagner, AM Buga, B Popescu… - Journal of neural …, 2015 - Springer
To a great extent, cognitive health depends on cerebrovascular health and a deeper
understanding of the subtle interactions between cerebrovascular function and cognition is …

Brain vasculature and cognition: Renin-angiotensin system, endothelin, and beyond

AY Fouda, SC Fagan, A Ergul - Arteriosclerosis, thrombosis, and …, 2019 - Am Heart Assoc
There is a complex interaction between the brain and the cerebral vasculature to meet the
metabolic demands of the brain for proper function. Preservation of cerebrovascular function …