Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Abstract The World Health Organization reports that 47.5 million people are affected by
dementia worldwide. With aging populations and 7.7 million new cases each year, the …

Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Relationships between cardiovascular risk and disease, and dementia have been identified,
and the term vascular cognitive impairment (VCI) is used to describe individuals with …

A close relationship is emerging among the age-related neurodegenerative decline, and the
age-related typical alterations, dysfunctions, and related diseases of the cerobro-and/or …

The effects of the renin–angiotensin system (RAS) surpass the renal and cardiovascular
systems to encompass other body tissues and organs, including the brain. Angiotensin II …

Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Vascular pathology is the second most common neuropathology of dementia after
Alzheimer's disease (AD), with small vessels disease (SVD) being considered the major …

The association between cerebral small vessel disease (SVD)–in the form of white matter
lesions, infarctions, and hemorrhages–with vascular cognitive impairment (VCI), has mostly …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …