Vascular dementia accounts for approximately 20% of all cases of dementia and for about
50% in subjects over 80 years. Thromboembolism with multiple cerebral infarcts was …

As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …

Vascular dementia is, in its current conceptual form, a distinct type of dementia with a
spectrum of specific clinical and pathophysiological features. However, in a very large …

The “biomechanical hypothesis” stipulates that with aging, the cumulative mechanical
damages to the cerebral microvasculature, magnified by risk factors for vascular diseases …

Recent findings indicate that neurovascular dysfunction is an integral part of Alzheimer's
disease (AD). Changes in the vascular system of the brain may significantly contribute to the …

Background Small vessels have the pivotal role for the brain's autoregulation. The
arteriosclerosis-dependent alteration of the brain perfusion is one of the major determinants …

Cerebrovascular disease typically manifests with stroke, cognitive impairment, or both.
Vascular cognitive impairment refers to all forms of cognitive disorder associated with …

The aging of the central nervous system and the development of incapacitating neurological
diseases like Alzheimer's disease (AD) are generally associated with a wide range of …

Neurons and glial cells in the brain are protected by the blood brain barrier (BBB). The local
regulation of blood flow is determined by neurons and signal conducting cells called …

The term vascular cognitive impairment (VCI) was introduced around the start of the new
millennium and refers to the contribution of vascular pathology to any severity of cognitive …